Answer
Nov 21, 2024 - 01:31 PM
The most serious side effect of allopurinol is a severe hypersensitivity reaction known as allopurinol hypersensitivity syndrome (AHS). This can include symptoms such as rash, fever, eosinophilia, hepatitis, and renal failure, and in rare cases, it can lead to Stevens-Johnson syndrome or toxic epidermal necrolysis, which are life-threatening skin conditions. Due to these risks, careful monitoring is essential, particularly in patients with renal impairment or those starting treatment.
