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Yes, Tazorac® (tazarotene) and Fosamax® (alendronate) can generally be used together; no specific clinically significant interaction is listed between them. Tazorac is a topical retinoid, while Fosamax is an oral bisphosphonate, so they do not have an obvious absorption conflict with each other.
A few practical cautions:
Bottom line: They are generally compatible, but the patient should follow Fosamax administration instructions carefully and avoid Tazorac if pregnant, trying to conceive, or unable to use effective contraception.
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