Answer
Apr 04, 2025 - 03:26 PM
Canagliflozin carries a black box warning for an increased risk of lower limb amputations, particularly affecting the toes, feet, and legs. Patients with a history of prior amputations, peripheral vascular disease, neuropathy, or diabetic foot ulcers are at higher risk. It is essential for healthcare providers to monitor patients for signs of infection, sores, or ulcers and to consider these risks when prescribing canagliflozin.
