Answer
Jun 19, 2025 - 11:00 AM
Isosorbide mononitrate should not be taken with phosphodiesterase inhibitors such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra), as the combination can lead to a significant and potentially dangerous drop in blood pressure. Additionally, caution should be exercised when using it with other blood pressure-lowering medications or alcohol, as these can also enhance its hypotensive effects. Always consult a healthcare provider for personalized advice.