Answer
Jan 22, 2026 - 01:02 PM
Valdoxan acts as an agonist at MT1 and MT2 melatonergic receptors and as an antagonist at 5-HT2C receptors. MT1 and MT2 are melatonin receptors that help regulate the body’s circadian rhythm, and 5-HT2C is a serotonin receptor linked to mood regulation. This unique mechanism can help re-synchronize sleep and mood cycles, which is valuable for people whose depression includes sleep disturbances.
