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Can you provide the protein binding percentage for Monoferric (Ferric Derisomaltose)? Monoferric (Ferric Derisomaltose)
Protein binding percentage for Monoferric® / ferric derisomaltose: Not reported / not specified.
The U.S. prescribing information does not provide a numeric plasma protein-binding percentage. In pharmacokinetics, it describes total iron as “derisomaltose-bound plus transferrin-bound iron,” and states that circulating iron is removed by reticuloendothelial-system cells, then bound to protein moieties to form hemosiderin or ferritin, or to a lesser extent transferrin.
The Canadian product monograph similarly does not list a protein-binding percentage; it states that circulating iron is “immediately bound” to protein moieties as hemosiderin/ferritin or, to a lesser extent, transferrin.
So for a drug-information table, I would enter:
Protein binding: Not reported; iron binds physiologically to ferritin/hemosiderin and transferrin after uptake/release from the ferric derisomaltose complex.
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Open Jun 16, 2026 - 02:07 PM
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