Answer
Jun 18, 2026 - 02:52 PM
Yes, Hadlima can be associated with weight gain, but it is not usually listed as a common “everyday” side effect like injection-site reactions, upper respiratory infections, headache, rash, or nausea. The official Hadlima site lists those as common side effects.
There are two main scenarios:
Gradual weight gain: This can happen in some people on TNF-blockers like adalimumab, possibly because inflammation improves, appetite returns, gut absorption improves, or activity changes. Research reviews have found TNF-alpha inhibitors may increase body weight/BMI in some patients, though the amount varies and may be modest.
Sudden weight gain: This is more concerning. Hadlima’s safety information specifically warns that new or worsening heart failure can cause symptoms such as shortness of breath, swelling of the ankles or feet, and sudden weight gain. You should contact your doctor promptly or seek urgent care if those symptoms occur.
A good rule: a few pounds gradually may be worth discussing at your next appointment, but rapid gain, swelling, or breathlessness should be checked right away. Also consider other contributors, especially steroids like prednisone, diet/appetite changes, fluid retention, reduced activity, or the condition being treated.
