Answer
Jun 22, 2026 - 02:45 PM
Usual Daily Dose of Braftovi (Encorafenib)
The usual daily dose of Braftovi (encorafenib) depends on the cancer type and combination treatment.
| Indication | Usual Braftovi Dose |
|---|---|
| Melanoma with BRAF V600E/V600K mutation, used with binimetinib (Mektovi) | 450 mg by mouth once daily Usually six 75 mg capsules |
| Metastatic NSCLC with BRAF V600E mutation, used with binimetinib | 450 mg by mouth once daily Usually six 75 mg capsules |
| Metastatic colorectal cancer with BRAF V600E mutation, used with cetuximab ± chemotherapy | 300 mg by mouth once daily Usually four 75 mg capsules |
Braftovi may be taken with or without food, and treatment is generally continued until disease progression or unacceptable toxicity.
Dose reductions are common when side effects occur or if certain interacting medicines are used, so the prescribed dose may be lower for an individual patient.
